Record Details

Carrier Risk Calculations for Recessive Diseases when all the Mutant Alleles are not Detectable

Pakistan Journal of Statistics and Operation Research

View Archive Info
 
 
Field Value
 
Title Carrier Risk Calculations for Recessive Diseases when all the Mutant Alleles are not Detectable
 
Creator Khattak, Mahnaz
Shah, Shuhrat
Jan, Bahrawar
 
Description There are certain recessive diseases in which some of mutations causing the disease, can be detected using the genetic probabilities. For counseling purposes, the probability that, a consultand known not to have a detectable mutation, a carrier needs to be calculated with as much accuracy as possible.
A method for the carrier risk calculation is proposed, which is based on information on the parents, one or two sibs and one or two children as well as on the spouse of the consultand in terms of positive or negative test results only, since genotype configurations for all of them may not be available in practice.
For a particular disease, the carrier risk is calculated by its incidence and the proportion of the mutations that are detectable, the table once produced can be used for any family of the types included.
 
Publisher College of Statistical and Actuarial Sciences
 
Date 2007-07-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://www.pjsor.com/index.php/pjsor/article/view/64
10.18187/pjsor.v3i2.64
 
Source Pakistan Journal of Statistics and Operation Research; Vol 3. No. 2, July 2007; 103-108
2220-5810
1816-2711
 
Language eng
 
Relation http://www.pjsor.com/index.php/pjsor/article/view/64/43