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Application and Analysis of a Cross-Over Design

Pakistan Journal of Statistics and Operation Research

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Title Application and Analysis of a Cross-Over Design
Creator Lawrence, Clive J.
Kamal, Shahid
Lang, Sandra
Description In this paper we consider the application and analysis of a cross-over design in a medical problem. Some statistical detail is given of the linear model used and its analysis. This design is in the class of repeated measurement analyses which can, for the medical research worker, be a source of some difficulty. Its application to a study of the constituents of breast-milk, and their possible variation between hand and pump expression is examined. Data for this analysis comes from a study that has been carried out in Exeter, UK, in which information was collected on a number of different aspects of infant feeding. Results for sodium, potassium, and other constituents are reported, together with some discussion of the various practical difficulties that can arise in the organisation of studies of this kind. Comments are included concerning the extension from two to three-period designs, and in the testing of significance.
Publisher College of Statistical and Actuarial Sciences
Date 2005-07-01
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Source Pakistan Journal of Statistics and Operation Research; Vol 1. No. 1, July 2005; 7-14
Language eng