Record Details

On Some Aspects of Conditional Power Evaluation In Two-phase Clinical Trials Under Linear Regression

Pakistan Journal of Statistics and Operation Research

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Field Value
 
Title On Some Aspects of Conditional Power Evaluation In Two-phase Clinical Trials Under Linear Regression
 
Creator Hedayat, A. S.; Department of Mathematics, Statistics, and Computer Science
University of Illinois at Chicago
Sinha, Bikas K.; Bayesian & Interdisciplinary Research Unit (BIRU)
Indian Statistical Institute, Kolkata
Wei, Li; Global Biometric Science
Bristol-Myers Squibb Company
 
Subject Statistics
Interim analysis, Regression models, Conditional probability

 
Description We investigate the conditional power under the framework of linear regression models so that it can be applied to most actual clinical trials in which multiple treatment effects and covariate effects are included. It is well known that the standard power of a regular test for a treatment contrast depends on unknown parameters only through the contrast itself. However it is not true in general for conditional power. Conditions for this to happen are established here and some instances are illustrated. We also show that similar arguments can be made about the sufficient statistics for the conditional power.
 
Publisher College of Statistical and Actuarial Sciences
 
Contributor
 
Date 2012-07-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://www.pjsor.com/index.php/pjsor/article/view/516
10.18187/pjsor.v8i3.516
 
Source Pakistan Journal of Statistics and Operation Research; Vol 8. No. 3, 2012; 393-413
2220-5810
1816-2711
 
Language eng
 
Relation http://www.pjsor.com/index.php/pjsor/article/view/516/249